Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules Using a pH-Low Insertion Peptide
نویسندگان
چکیده
منابع مشابه
Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide.
Drug molecules are typically hydrophobic and small in order to traverse membranes to reach cytoplasmic targets, but we have discovered that more polar molecules can be delivered across membranes using water-soluble, moderately hydrophobic membrane peptides of the pHLIP (pH low insertion peptide) family. Delivery of polar cargo molecules could expand the chemical landscape for pharmacological ag...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2020
ISSN: 1543-8384,1543-8392
DOI: 10.1021/acs.molpharmaceut.9b00883